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KMID : 1101320040360010049
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Korean Journal of Clinical Laboratory Science
2004 Volume.36 No. 1 p.49 ~ p.54
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Changes of Serum Lipid after Treatement of Lycii fructus Extract in Hyperlipemia Rats
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Cho Jung-Hee
Sin Ji-Soon
Bae Hyung-Joon
Kim Yun-Bae
Kang Jong-Koo
Hwang Seock-Yeon
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Abstract
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The purpose of this study was to investigate the effects of Lycii fructus extract on the serum lipids in hyperlipemia rats. The rats were divided five groups including negative control, positive control and treated L. fructus extract at dose of 50, 100, 200 mg/kg. To induce the hyperlipemia, 4 groups of rats, not including the negative control group, were fed experimental diets consisting of cholesterol, lard, corn oil, and normal diet for experiment period. As a result, the L. fructus extract decreased total cholesterol(T. Cho), trigryceride(TG), low density lipoprotein cholesterol(LDL-C), and free fatty acid(FFA) significantly compared with positive control. However, no significant difference was found in high density lipoprotein(HDL-C) and phospholipid(PPL) level. Otherwise, in serum lipid level including, T-Cho, TG, LDL-C, FFA and PPL was decreased dose dependently by treatment of L. fructus extract. But HDL-C was increased by L. fructus extract too. Thereby having beneficial effect on hyperlipermia by influencing the serum lipid change, it is expected that Lycii fructus extract can suppress arteriosclerosis and obesity.
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KEYWORD
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Lycii fructus, Hyperlipemia
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